Encourage Your Patients to Participate! US-Based Clinical Trials That Are Actively Recruiting in Gallbladder and Biliary Tract Cancer

Clinical trial recruitment and retention remain challenges in the quest to bring innovative therapies to all patients in need. In oncology, therapies continue to evolve, yet researchers are frequently faced with low trial participation, particularly among minority groups. Oncology Practice Management (OPM) is dedicated to providing comprehensive information aimed at eliminating health disparities and improving access to therapies for people from all populations, including racial and ethnic minorities; people with limited access to healthcare due to lack of financial resources; and people living in rural communities.

This new feature in OPM aims to provide ongoing lists of US-based phase 2 or 3 clinical trials that are actively recruiting. Healthcare practitioners may use this listing in discussions with their patients to encourage enrollment. As the National Comprehensive Cancer Network has stated, “The best management of any cancer patient is in a clinical trial.”

These clinical trial listings can be found at www.ClinicalTrials.gov.

Testing the Combination of New Anticancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
• ClinicalTrials.gov Identifier: NCT04068194
• Conditions:
• Cholangiocarcinoma
• Gallbladder Carcinoma
• Stage III Gallbladder Cancer AJCC v8
• Stage IV Gallbladder Cancer AJCC v8
• Locations: 42 locations

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd-Line Setting (A ComboMATCH Treatment Trial)
• ClinicalTrials.gov Identifier: NCT05564403
• Status: Recruiting
• Conditions:
• Stage III Gallbladder Cancer AJCC v8
• Stage IV Gallbladder Cancer AJCC v8
• Advanced Gallbladder Carcinoma
• Advanced Biliary Tract Carcinoma
• Locations: 185 throughout the country

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases
• ClinicalTrials.gov Identifier: NCT05285358
• Status: Recruiting
• Conditions:
• Gallbladder Carcinoma
• Distal Bile Duct Adenocarcinoma
• Intrahepatic Cholangiocarcinoma
• Metastatic Malignant Neoplasm in the Peritoneum
• Location:
• Duarte, CA

Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
• ClinicalTrials.gov Identifier: NCT06109779
• Condition:
• Biliary Tract Cancer
• Locations:
• Birmingham, AL
• Phoenix, AZ
• Duarte, CA
• Los Angeles, CA

Locally Ablative Therapy for Oligo-progressive Gastrointestinal Malignancies (LIVELONG)
• ClinicalTrials.gov Identifier: NCT06101277
• Conditions:
• Gallbladder Cancer
• Appendiceal Cancer
• Biliary Cancer
• Colorectal Cancer
• Location:
• Sacramento, CA

Comparison of Duodenoscope With Single-Use Distal Cover and the Conventional Reusable Duodenoscope
• ClinicalTrials.gov Identifier: NCT05429203
• Conditions:
• Biliary Disease
• Biliary Obstruction
• Biliary Tract Neoplasms
• Choledocholithiasis

Efficacy and Safety of Zanidatamab With Standard-of-Care Therapy Against Standard-of-Care Therapy for Advanced HER2-Positive Biliary Tract Cancer
• ClinicalTrials.gov Identifier: NCT06282575
• Conditions:
• Biliary Tract Cancer
• HER2 Gene Mutation
• Locations:
• Lone Tree, CO
• Orlando, FL
• Atlanta, GA
• Westwood, KS

Virtual Reality for GI Cancer Pain to Improve Patient-Reported Outcomes
• ClinicalTrials.gov Identifier: NCT04907643
• Conditions:
• Bile Duct Cancer
• Bile Duct Cancer Recurrent
• Bile Duct Cancer Stage I
• Bile Duct Cancer Stage II
• Location:
• Los Angeles, CA

Integrated Cancer Repository for Cancer Research
• ClinicalTrials.gov Identifier: NCT02012699
• Conditions:
• Bile Duct Cancer
• Gallbladder Cancer
• Anal Cancer
• Bladder Cancer
• Location:
• Colorado Springs, CO
• Denver, CO
• Durango, CO
• Lakewood, CO
• Palo Alto, CA