Clinical trial recruitment and retention remain challenges in the quest to bring innovative therapies to all patients in need. In oncology, therapies continue to evolve, yet researchers are frequently faced with low trial participation, particularly among minority groups. Oncology Practice Management (OPM) is dedicated to providing comprehensive information aimed at eliminating health disparities and improving access to therapies for people from all populations, including racial and ethnic minorities, people with limited access to healthcare due to lack of financial resources, and people living in rural communities.
This feature in OPM aims to provide ongoing lists of US-based trials that are actively recruiting. This issue is focused on pancreatic cancer because November is Pancreatic Cancer Awareness Month. Healthcare practitioners may use this listing in discussions with their patients to encourage enrollment. As the National Comprehensive Cancer Network has stated, “The best management of any cancer patient is in a clinical trial.”
These clinical trial listings can be found at www.ClinicalTrials.gov.
Super-enhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas
ClinicalTrials.gov identifier: NCT04896073
Sponsor: National Cancer Institute
Conditions: Adenosquamous carcinoma of the pancreas
Location: Bethesda, Maryland
Study of IPMN Progression Prevention With Tocotrienol (SIPP-T3)
ClinicalTrials.gov identifier: NCT06519097
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Conditions: Neoplasm of pancreas, pancreatic cancer
Locations: Tampa, Florida; Omaha, Nebraska
Evaluation of Outcomes From Treatment of Benign or Malignant Gastroesophageal Diseases
ClinicalTrials.gov identifier: NCT04637256
Sponsor: Methodist Health System
Conditions: Pancreatic malignant neoplasm primary
Location: Richardson, Texas
Evaluation of Endoscopic Ultrasound-Guided Radiofrequency Ablation for the Management of Pancreatic Tumors, ERASE Study
ClinicalTrials.gov identifier: NCT05961982
Sponsor: Ohio State University Comprehensive Cancer Center
Conditions: Pancreatic neoplasm
Location: Columbus, Ohio
CAR T Cell Immunotherapy for Pancreatic Cancer
ClinicalTrials.gov identifier: NCT03323944
Sponsor: University of Pennsylvania
Conditions: Pancreatic cancer
Location: Philadelphia, Pennsylvania
Use of Indocyanine Green in Pancreas Surgery
ClinicalTrials.gov identifier: NCT06084013
Sponsor: OHSU Knight Cancer Institute
Conditions: Pancreatic carcinoma
Location: Portland, Oregon
Pilot Study of Pancreatic Cancer Screening
ClinicalTrials.gov identifier: NCT05058846
Sponsor: University of California, San Francisco
Conditions: Pancreatic cancer, pancreatic neoplasms
Location: San Francisco, California
A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion
Clinicaltrials.gov identifier: NCT06360354
Sponsor: Amgen
Conditions: Advanced gastrointestinal, biliary tract, and pancreatic cancers
Locations: Bakersfield, Duarte, Los Angeles, and Santa Monica, California
Comparing Two Methods to Follow Patients With Pancreatic Cysts
Clinicaltrials.gov identifier: NCT04239573
Sponsor: ECOG-ACRIN Cancer Research Group
Conditions: Pancreatic carcinoma
Locations: 328 throughout the United States
Determining Individualized Cancer Therapy in Pancreatic Cancer
Clinicaltrials.gov identifier: NCT05914987
Sponsor: Medical College of Wisconsin
Conditions: Pancreatic neoplasms
Location: Milwaukee, Wisconsin
Molecular Detection of Advanced Neoplasia in Pancreatic Cysts
Clinicaltrials.gov identifier: NCT03855800
Sponsor: Mayo Clinic
Conditions: Pancreas cyst
Location: Rochester, Minnesota
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
ClinicalTrials.gov identifier: NCT06411795
Sponsor: Masonic Cancer Center, University of Minnesota
Conditions: Pancreatic and duodenal neoplasms per trial page
Location: Minneapolis, Minnesota
A Pancreatic Cancer Screening Study in Hereditary High-Risk Individuals
ClinicalTrials.gov identifier: NCT03250078
Sponsor: Nuvance Health
Conditions: Pancreatic neoplasms
Location: Norwalk, Connecticut
Promoting CT Engagement for Pancreatic Cancer With App
ClinicalTrials.gov identifier: NCT06252545
Sponsor: UNC Lineberger Comprehensive Cancer Center
Conditions: Pancreas cancer
Locations: Chapel Hill, North Carolina; Milwaukee, Wisconsin
Molecular Profile-Related Individualized Targeted Therapy in Resected Pancreatic Cancer With High Risk of Cancer Recurrence
ClinicalTrials.gov identifier: NCT06228599
Sponsor: Medical College of Wisconsin
Conditions: Pancreas cancer
Location: Milwaukee, Wisconsin
Collection of Circulating Biomarkers in Pancreatic Cancer
ClinicalTrials.gov identifier: NCT05743049
Sponsor: Abramson Cancer Center at Penn Medicine
Conditions: Pancreas cancer
Location: Philadelphia, Pennsylvania
A Supervised Prehabilitation Program for Patients With Pancreatic Cancer
ClinicalTrials.gov identifier: NCT05692323
Sponsor: Cedars-Sinai Medical Center
Conditions: Pancreas cancer
Location: Los Angeles, California
The Cancer of the Pancreas Screening-5 (CAPS5) study
ClinicalTrials.gov identifier: NCT02000089
Sponsor: Johns Hopkins University
Conditions: Pancreas cancer, gene mutation, germline mutation carrier, Lynch Syndrome, Peutz-Jeghers Syndrome
Locations: New Haven, Connecticut; Baltimore, Maryland; Massachusetts, Michigan, New York, Ohio, Pennsylvania
Neoantigen Vaccines in Pancreatic Cancer in the Window Prior to Surgery
ClinicalTrials.gov identifier: NCT05111353
Sponsor: Washington University School of Medicine
Conditions: Pancreatic cancer
Location: Saint Louis, Missouri
Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic Adenocarcinoma
ClinicalTrials.gov identifier: NCT05241249
Sponsor: Susan E. Bates
Conditions: Pancreas cancer
Location: New York, New York
A Pancreatic Cancer Screening Study in Individuals With New-Onset or Deteriorating Diabetes Mellitus
ClinicalTrials.gov identifier: NCT03937453
Sponsor: Nuvance Health
Conditions: Pancreatic neoplasms and pancreatic cancer
Location: Norwalk, Connecticut
Red Blood Cell Transfusion Thresholds for Improved Quality of Life for Patients Undergoing a Pancreatectomy for Pancreatic Cancer
ClinicalTrials.gov identifier: NCT05841706
Sponsor: Jonsson Comprehensive Cancer Center
Conditions: Resectable pancreatic carcinoma
Location: Los Angeles, California
L-DOS47 Plus Doxorubicin in Advanced Pancreatic Cancer
ClinicalTrials.gov identifier: NCT04203641
Sponsor: Helix BioPharma Corporation
Conditions: Pancreas cancer
Locations: Scottsdale, Arizona; Morristown, New Jersey; Milwaukee, Wisconsin
Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
ClinicalTrials.gov identifier: NCT03484299
Sponsor: University of Louisville
Conditions: Pancreas cancer
Location: Louisville, Kentucky
Evaluation of Resection Techniques for Pancreatic Tumors
ClinicalTrials.gov identifier: NCT05128890
Sponsor: Methodist Health System
Conditions: Pancreas and liver tumors, surgery
Location: Dallas, Texas
Switch Maintenance in Pancreatic Cancer
ClinicalTrials.gov identifier: NCT05419479
Sponsor: James Cleary, MD, PhD; Dana-Farber Cancer Institute (Responsible Party)
Conditions: Pancreatic cancer, adenocarcinoma of the pancreas, adenosquamous carcinoma of the pancreas, squamous cell carcinoma of pancreas
Location: Boston, Massachusetts
Genetic Predisposition Testing Program for Pancreatic Neuroendocrine Neoplasms
ClinicalTrials.gov identifier: NCT05746182
Sponsor: University of California, San Francisco
Conditions: Pancreatic neuroendocrine neoplasm
Locations: Los Angeles, San Diego, and San Francisco, California
Diagnostic Strategies, Risk Assessment and Progression of Pancreatic Cysts
ClinicalTrials.gov identifier: NCT04473794
Sponsor: Johns Hopkins University
Conditions: Pancreas cancer and pancreatic neoplasms
Location: Baltimore, Maryland