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April 2024, Vol 14, No 4

Recognizing the complexities of treatment with oral medications is an important step toward successful outcomes. Read More ›

The FDA recently announced the publication of an article reviewing 50 years of the FDA’s experience with clinical research related to the use of cannabis in drug development. Read More ›

The addition of pembrolizumab to standard-of-care FLOT (docetaxel, oxaliplatin, leucovorin, and 5-fluorouracil) prolongs pathologic complete response (pCR) and event-free survival (EFS) in patients with resectable gastric and gastroesophageal junction (G/GEJ) adenocarcinoma. Read More ›

The addition of durvalumab and bevacizumab to transarterial chemoembolization (TACE) significantly improved progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (HCC) eligible for embolization. Read More ›

The combination of cabozantinib and atezolizumab improved radiographic progression-free survival (rPFS) versus a switch to a second novel hormonal agent (NHT) in patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed on a first NHT, according to findings from the phase 3 CONTACT-02 trial. Read More ›

For the first time, an adjuvant treatment has led to a survival benefit in clear cell renal cell carcinoma (ccRCC). Data from the multicenter phase 3 KEYNOTE-564 study demonstrate that adjuvant pembrolizumab led to a 38% lower risk of death compared with placebo among patients with ccRCC who had a high risk of recurrence after surgery. The findings were presented by Toni K. Choueiri, MD, at the 2024 ASCO Genitourinary Cancers Symposium. Read More ›

A subcutaneous (SC) form of nivolumab was just as effective as IV nivolumab on progression-free survival (PFS) in patients with previously treated advanced renal cell carcinoma (ccRCC), with no increase in hypersensitivity reactions. The SC form is more convenient and less time consuming to administer, with an average administration time of 5 minutes or less. Read More ›