In this 3-part series, Joyce O’Shaughnessy, MD, and Marissa Marti-Smith, DNP, APRN, AGNP-C, AOCNPO, explore complementary approaches to the treatment of 2 patients with breast cancer who have specific characteristics associated with a high risk of recurrence. Together, these perspectives underscore the multifaceted approach needed for effective risk assessment in early-stage breast cancer.