Conference Correspondent

Tucatinib added to trastuzumab and capecitabine resulted in a substantial and permanent improvement of progression-free survival and overall survival for all patients with HER2-positive metastatic breast cancer with brain metastases, as confirmed by results from the HER2CLIMB study. Read More ›

Tucatinib-containing therapy resulted in a tumor volume reduction of >80%. Tucatinib was found to be highly effective when combined with paclitaxel plus trastuzumab plus pertuzumab. Read More ›

Tyrosine kinase inhibitor (TKI) treatments show equal overall survival and progression-free survival (PFS) benefits in patients with HER2-positive breast cancer with and without brain metastases. Read More ›

The combination regimen of tucatinib, palbociclib, and letrozole in patients with hormone receptor–positive, HER2-positive breast cancer with brain metastases demonstrates an improved central nervous system progression-free survival in a small group of patients. Read More ›

Tucatinib-trastuzumab-capecitabine combination therapy has been shown to double the overall survival in patients with HER2-positive breast cancer with leptomeningeal metastases. Read More ›

Patients with myelofibrosis who are intolerant, refractory to, or ineligible for JAK inhibitor therapy such as ruxolitinib are generally difficult to treat and have poor prognoses. Evidence suggests pelabresib can safely and effectively improve clinical outcomes in this patient subset. Read More ›

For patients with myelofibrosis, fedratinib has emerged as another option for first-line therapy after prior ruxolitinib therapy. In a real-world setting, data indicate earlier initiation of fedratinib may be of clinical benefit in this patient population. Read More ›

Previous studies have established a role for TGFβ in promoting development and progression of myelofibrosis. Evidence suggests AVID200, a TGFβ1/3 inhibitor, may modulate TGFβ signaling mechanisms associated with myelofibrosis. Read More ›

Fedratinib, a JAK2 inhibitor, was recently approved to treat myelofibrosis in patients previously treated with ruxolitinib. Evidence suggests fedratinib may be a viable therapeutic option to improve survival in this patient population. Read More ›

The rate of thrombus formation in patients with myelofibrosis is not well-defined. The intersection of IPSS score and JAK mutation may reliably indicate risk of vascular events in these patients. Read More ›