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By William King
In a keynote address during the virtual 2020 International Kidney Cancer Symposium, William G. Kaelin, Jr, MD, Sidney Farber Professor of Medicine, Dana-Farber Cancer Institute, Boston, MA, provided an update on treatment strategies aimed at improving outcomes for patients with clear-cell renal-cell carcinoma (RCC) caused by inactivation of the VHL gene. Promising therapies include immunotherapies, hypoxia-inducible factor (HIF)-2α inhibitors, and cyclin-dependent kinase (CDK)4/6 inhibitors. Read More ›
First-Line Combinations Show Promise in the Treatment of Patients with Advanced Renal-Cell Carcinoma
By William King
The treatment of renal-cell carcinoma (RCC) continues to evolve with the development of more effective frontline regimens. During the virtual 2020 International Kidney Cancer Symposium, experts discussed the expanding role of several of these therapies, including tyrosine kinase inhibitors (TKIs) and immunotherapies, which are being evaluated in various combinations to improve outcomes for patients with advanced and high-risk disease. Read More ›
On February 3, 2021, the FDA accelerated the approval of tepotinib (Tepmetko; EMD Serono), an oral MET kinase inhibitor, for the treatment of patients with metastatic non–small-cell lung cancer (NSCLC) who harbor MET exon 14 skipping alterations. Read More ›
On January 22, 2021, the FDA approved the combination of nivolumab (Opdivo; Bristol Myers Squibb), an immune checkpoint inhibitor, and cabozantinib (Cabometyx; Exelixis), a tyrosine kinase inhibitor, for the first-line treatment of patients with advanced renal-cell carcinoma. Read More ›
On January 14, 2021, the FDA approved crizotinib (Xalkori; Pfizer), an oral tyrosine kinase inhibitor, for the treatment of pediatric patients aged ≥1 years and young adults with relapsed or refractory systemic ALK-positive anaplastic large-cell lymphoma (ALCL). The safety and efficacy of crizotinib have not been established in older adults with relapsed or refractory systemic ALK-positive ALCL. Read More ›
The following clinical trials represent a selection of key studies currently recruiting patients with gynecologic cancers for inclusion in investigations of new therapies and new regimens of existing treatments for the disease. Each clinical trial description includes the NLM Identifier to be used as a reference with ClinicalTrials.gov. This information can help oncology practice managers and providers direct eligible patients to one of these clinical trials. Read More ›
Watch this webinar to learn how harnessing the power of advanced data science and machine learning can allow infusion centers to schedule their patient volume more strategically, which in turn unlocks capacity that would have otherwise gone unused. The more efficient use of existing resources ultimately results in infusion centers being able to handle more appointments and provide better access to new and existing patients. Read More ›
Over the past year, the COVID-19 pandemic has ushered in unprecedented changes in the practice of medicine and dissemination of treatment advances presented in scientific forums. Read More ›
Overall response rate, duration of response, and media progression-free survival were highest in the group of treatment-naïve patients with T790M negativity and any MET mutation. Read More ›
US Food and Drug Administration–approved capmatinib is an effective second-line treatment for patients with MET exon 14–mutated NSCLC. Read More ›