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Ovarian cancer—including epithelial cancer, fallopian tube cancer, and primary peritoneal cancer—often affects women aged 55 to 64 years, with nearly 70% of all cases occurring in women aged ≥45 years. In 2020, an estimated 21,750 women will be newly diagnosed with ovarian cancer, and approximately 13,940 women will die from this disease in the United States. Read More ›

Lung and bronchus cancer is the second most prevalent form of cancer in the United States.¹ Representing 12.7% of all new cancer cases, lung cancer was diagnosed in 228,820 individuals in 2020. It is the leading cause of cancer-related mortality in men and women, accounting for 22.4% of all cancer deaths. Read More ›

Epithelioid sarcoma is a rare subtype of soft-tissue sarcoma that most often occurs in the soft tissue of the fingers, hands, and forearms, but that can occur in other areas of the body. In 2005 in the United States, the incidence of epithelioid sarcoma was approximately 0.04 cases per 100,000 people. Epithelioid sarcoma predominantly affects young adults; however, it can affect individuals at any age and is more prevalent in males than in females. Characterized by slow tumor growth and benign manifestations at early stages, epithelioid sarcoma can be challenging to diagnose. Read More ›

Rumors about the entry of Amazon into the healthcare arena have been circulating for years. Now, it has become a reality in all 50 states. Although there is no guarantee that this venture will be successful, it is likely to become a seismic event for all healthcare providers and patients. Therefore, it is important to acknowledge and address its potential impact sooner rather than later. Read More ›

Pembrolizumab (Keytruda) plus chemotherapy improved progression-free survival (PFS) compared with chemotherapy alone as first-line treatment of metastatic triple-negative breast cancer (TNBC), according to the results of KEYNOTE-355. Improvement in PFS with the addition of pembrolizumab to chemotherapy was more robust in patients with TNBC and PD-L1 expression. These results were presented at the virtual 2020 San Antonio Breast Cancer Symposium (SABCS) and add to a growing body of evidence supporting the first-line use of pembrolizumab plus chemotherapy combinations for TNBC. Read More ›

The combination of nivolumab (Opdivo) plus cabozantinib (Cabometyx) continued to show superior survival outcomes compared with single-agent sunitinib (Sutent) as first-line treatment for patients with advanced renal-cell carcinoma (RCC), according to extended follow-up data from the phase 3 CheckMate-9ER clinical trial presented at the 2021 ASCO Genitourinary Cancers Symposium. Read More ›

The addition of the cyclin-dependent kinase (CDK)4/6 inhibitor abemaciclib (Verzenio) to standard endocrine therapy reduced the risk for invasive disease recurrence or death compared with endocrine therapy alone by almost 30% in patients with high-risk, hormone receptor (HR)-positive, human epidermal growth receptor 2 (HER2)-negative, early-stage breast cancer. These results come from the primary analysis of the phase 3 monarchE clinical trial that was presented at the virtual 2020 San Antonio Breast Cancer Symposium. Read More ›

Results of the SWOG S1007 RxPONDER clinical trial suggest that some postmenopausal women with early-stage hormone receptor (HR)-positive, human epidermal growth receptor 2 (HER2)-negative breast cancer, and 1 to 3 positive axillary lymph nodes may be able to avoid adjuvant chemotherapy. By contrast, premenopausal women can derive benefit from adjuvant chemotherapy, based on findings of a prespecified interim analysis of the phase 3 RxPONDER clinical trial; the findings were presented at the virtual 2020 San Antonio Breast Cancer Symposium. Read More ›