Conference Correspondent

ASCO 2020 Lung Cancer Highlights

Although the American Society of Clinical Oncology (ASCO) 2020 meeting was held virtually because of the COVID-19 pandemic, hundreds of abstracts, posters, and presentations were still made available to inform clinicians on the latest developments in the treatment of lung cancer. This publication features some of the key highlights from the meeting, which can be used to improve the management and care of patients with the disease.

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Pragmatic setting administration of the all-oral combination of pomalidomide plus cyclophosphamide/dexamethasone (POMCIDEX) is a manageable, effective treatment option for patients with relapsed/refractory multiple myeloma. Read More ›

Based on early results of a dose-escalation study, teclistamab demonstrated an overall response rate of 67% at the highest dose, as well as reasonable tolerability with low incidence of high-grade cytokine release syndrome in patients with advanced relapsed/refractory multiple myeloma. Read More ›

Isatuximab plus carfilzomib/dexamethasone (IKEMA study) shows promising efficacy and tolerable safety in prolonging progression-free survival compared with carfilzomib/dexamethasone alone in the treatment of patients with RRMM. Read More ›

Efficacy and toxicity outcome measures with daratumumab added to carfilzomib/dexamethasone were consistent across subgroups within the CANDOR trial, regardless of lenalidomide- or bortezomib-refractory status or number of previous treatments. Read More ›

A systematic literature review to investigate evidence for therapies in patients with RRMM suggests there is limited published efficacy data available to support treatment options for heavily pretreated patients with RRMM. Read More ›

Idecabtagene vicleucel resulted in an overall response rate of 73% and demonstrated a tolerable safety profile in heavily pretreated patients who were refractory to their last regimen in the KarMMa trial. Read More ›

An update from the phase 1b/2 CARTITUDE study reveals early, deep, and durable responses and a manageable safety profile from treatment of patients with advanced RRMM with JNJ-4528 CAR T-cells. Read More ›

Ixazomib provided as part of an early access program in Europe resulted in a 58% overall response rate in an observational multicenter cohort study (UVEA-IXA) supporting the effectiveness of the drug in a real-world setting. Read More ›

In the GMMG-Concept trial, the addition of isatuximab to carfilzomib/lenalidomide/ dexamethasone in newly diagnosed high-risk patients with multiple myeloma led to an approximately 90% rate of very good partial response or better with manageable toxicity. Read More ›

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