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Breast Cancer

Despite their frailty and comorbidities in the elderly patient population, palbociclib was proven to be a well-tolerated treatment in elderly patients with advanced, ER-positive, HER2-negative breast cancer. Read More ›

A completion of local treatment and neoadjuvant or adjuvant chemotherapy results in significantly longer survival, free of invasive or distant disease than placebo in patients with high-risk, HER2-negative early breast cancer, with germline BRCA1 or BRCA2 pathogenic variants. Read More ›

Earlier this year, the independent data monitoring committee concluded that the OlympiA trial crossed the superiority boundary for its primary end point of invasive disease-free survival and demonstrated a sustainable, clinically relevant treatment effect for olaparib versus placebo in patients with germline BRCA mutation–positive, high-risk, HER2-negative, early breast cancer. Read More ›

Patients with HR-positive, HER2-negative metastatic breast cancer are more likely to have disease response to palbociclib plus letrozole versus letrozole alone, according to a real-world study. However, in real-world practice, there is less information on the tumor response of palbociclib plus an aromatase inhibitor versus an aromatase inhibitor alone. Read More ›

Clinical studies have demonstrated that olaparib is clinically efficacious in patients with germline BRCA mutation–positive, HER2-negative metastatic breast cancer in a setting closely resembling the real world. Read More ›

A real-world investigation has found that CDK4/6 inhibitor treatment outcomes are worse in patients with germline BRCA mutation–positive metastatic breast cancer than in patients with germline BRCA wild-type disease and unclear germline BRCA status, implying possible changes in tumor biology. Read More ›

PARP inhibitors offer the possibility of biomarker-targeted treatment for breast cancer. Therefore, it is necessary to quickly identify which patients may benefit from treatment and to guarantee that genetic testing is available. Read More ›

Adding CDK4/6 inhibitors to fulvestrant resulted in an improvement in overall survival. These findings back up the current standard of care of CDK4/6 inhibitors plus fulvestrant for patients with HR-positive, HER2-negative, advanced breast cancer. Read More ›

In a real-world study, more than 60% of the HR-positive, HER2-negative advanced breast cancer samples had ≥1 disease-related poor prognostic factors. The need for more effective CDK4/6 inhibitor medication in these individuals is highlighted by their increased pain and impaired performance status. Read More ›

Results of a recent web-based survey show that survey respondents are in favor of several changes in breast cancer treatment during COVID-19. These changes must be discussed on a local level, taking into consideration the infrastructure and resources available. Read More ›

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