2020 Guide to Patient Support Services

Karyopharm Therapeutics

Karyopharm Therapeutics offers comprehensive patient support services through its KaryForward program to facilitate access to Karyopharm’s oncology medication, Xpovio (selinexor), including reimbursement support and patient financial assistance. Xpovio is a nuclear export inhibitor indicated, in combination with dexamethasone, for the treatment of relapsed or refractory multiple myeloma (Table).


KaryForward support services offer patients a comprehensive set of support services, including financial assistance for patients, such as copay support and other services; reimbursement support, such as insurance benefit investigation, prior authorization, and/or appeal assistance; and patient and caregiver resources, such as support from a dedicated Nurse Case Manager regarding prescription instructions and medication side effects.

Xpovio Co-Pay Card

The Xpovio Co-Pay Card program provides copay assistance to eligible patients with commercial insurance. Eligible patients may pay as little as $5 per month out of pocket for

Xpovio, with a maximum amount of $8000 per month and an annual cap of $25,000.

Xpovio Patient Assistance Program

The Xpovio Patient Assistance Program provides Xpovio free of charge to eligible patients who meet the requirement criteria.

Xpovio QuickStart Prescription Program

The Xpovio QuickStart prescription program is available to eligible patients who are receiving their first prescription of Xpovio and cannot establish coverage or verification of coverage within 5 business days.


Xpovio Co-Pay Card Program

To be eligible for the Xpovio Co-Pay Card program, patients must:

  • Be a resident of the United States or US territories
  • Have commercial insurance that covers Xpovio
  • Have a valid prescription for an FDA-approved indication of Xpovio
  • Not be uninsured or participate in any federal or state healthcare programs, including Medicare, Med­icaid, TRICARE, and Veterans Health Administration.

The Xpovio Co-Pay Card program is not valid for patients who are paying cash for Xpovio, when Xpovio is not covered by the patient’s commercial insurance, or when the patient’s plan reimburses the entire cost of Xpovio.

Xpovio Patient Assistance Program

Please call 877-527-9493 to inquire about the Xpovio Patient Assistance Program, including eligibility and enrollment. Financial verification is required.

Xpovio QuickStart Prescription Program

To be eligible for the Xpovio QuickStart prescription program, patients must:

  • Have received their first Xpovio prescription
  • Not be able to ascertain coverage or verification of coverage within 5 business days
  • Be enrolled in the KaryForward Support Services program.

Call 877-527-9493 for further details about the Xpovio QuickStart prescription program.


Enrollment in the Xpovio Co-Pay Card program and Xpovio Patient Assistance Program requires the completion and submission of the KaryForward Enrollment Form, available online. The completed enrollment form should be faxed to 833-589-1603. The type(s) of patient support services needed must be indicated on the form, and the patient and the prescribing physician are required to sign the application. Assistance with the enrollment process can be obtained by calling 877-527-9493.

Xpovio is dispensed through a specialty pharmacy. Xpovio may be sent to the preferred specialty pharmacy indicated on the enrollment form or to the patient’s home.


Patient support programs

Xpovio (selinexor)
Treatment of adults with relapsed or refractory multiple myeloma after ≥4 previous therapies in disease refractory to ≥2 proteasome inhibitors, ≥2 immunomodulatory agents, and an anti-CD38 monoclonal antibody, in combination with dexamethasone
Patient support programs

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